-
Input details of specimens into logs or computer systems.
-
Select banding methods to permit identification of chromosome pairs.
-
Extract, measure, dilute as appropriate, label, and prepare DNA for array analysis.
-
Stain slides to make chromosomes visible for microscopy.
-
Analyze chromosomes found in biological specimens to aid diagnoses and treatments for genetic diseases such as congenital disabilities, fertility problems, and hematological disorders.
-
Communicate to responsible parties unacceptable specimens and suggest remediation for future submissions.
-
Prepare biological specimens such as amniotic fluids, bone marrow, tumors, chorionic villi, and blood, for chromosome examinations.
-
Develop and implement training programs for trainees, medical students, resident physicians or post-doctoral fellows.
-
Select or prepare specimens and media for cell cultures using aseptic techniques, knowledge of medium components, or cell nutritional requirements.
-
Arrange and attach chromosomes in numbered pairs on karyotype charts, using standard genetics laboratory practices and nomenclature, to identify normal or abnormal chromosomes.
-
Harvest cell cultures using substances such as mitotic arrestants, cell releasing agents, and cell fixatives.
-
Evaluate appropriateness of received specimens for requested tests.
-
Input details of specimen processing, analysis, and technical issues into logs or laboratory information systems (LIS).
-
Summarize test results and report to appropriate authorities.
-
Examine chromosomes found in biological specimens to detect abnormalities.
-
Create chromosome images using computer imaging systems.
-
Communicate test results or technical information to patients, physicians, family members, or researchers.
-
Select appropriate methods of preparation and storage of media to maintain potential of hydrogen (pH), sterility, or ability to support growth.
-
Recognize and report abnormalities in the color, size, shape, composition, or pattern of cells.
-
Apply prepared specimen and control to appropriate grid, run instrumentation, and produce analyzable results.
-
Prepare slides of cell cultures following standard procedures.
-
Count numbers of chromosomes and identify the structural abnormalities by viewing culture slides through microscopes, light microscopes, or photomicroscopes.
-
Archive case documentation and study materials as required by regulations and laws.
-
Determine optimal time sequences and methods for manual or robotic cell harvests.
-
Identify appropriate methods of specimen collection, preservation, or transport.
-
Describe chromosome, FISH and aCGH analysis results in International System of Cytogenetic Nomenclature (ISCN) language.
-
Develop, implement, and monitor quality control and quality assurance programs to ensure accurate and precise test performance and reports.
-
Select appropriate culturing system or procedure based on specimen type and reason for referral.
-
Supervise subordinate laboratory staff.
-
Maintain laboratory equipment such as photomicroscopes, inverted microscopes, and standard darkroom equipment.