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Job Description

Analyze chromosomes found in biological specimens such as amniotic fluids, bone marrow, and blood to aid in the study, diagnosis, or treatment of genetic diseases.

Job Details

The SOC (Standard Occupational Classification) code is 29-2011.01

☝️ Information based on the reference occupation “Cytogenetic Technologists”.

Also Known As…

Tasks for “Research Laboratory Specialist (Research Lab Specialist)”

Extract, measure, dilute as appropriate, label, and prepare DNA for array analysis.
Examine chromosomes found in biological specimens to detect abnormalities.
Develop and implement training programs for trainees, medical students, resident physicians or post-doctoral fellows.
Determine optimal time sequences and methods for manual or robotic cell harvests.
Select appropriate methods of preparation and storage of media to maintain potential of hydrogen (pH), sterility, or ability to support growth.
Maintain laboratory equipment such as photomicroscopes, inverted microscopes, and standard darkroom equipment.
Describe chromosome, FISH and aCGH analysis results in Internations System of Cytogenetic Nomenclature (ISCN) language.
Communicate to responsible parties unacceptable specimens and suggest remediation for future submissions.
Count numbers of chromosomes and identify the structural abnormalities by viewing culture slides through microscopes, light microscopes, or photomicroscopes.
Archive case documentation and study materials as required by regulations and laws.
Prepare slides of cell cultures following standard procedures.
Communicate test results or technical information to patients, physicians, family members, or researchers.
Select appropriate culturing system or procedure based on specimen type and reason for referral.
Input details of specimen processing, analysis, and technical issues into logs or laboratory information systems (LIS).
Arrange and attach chromosomes in numbered pairs on karyotype charts, using standard genetics laboratory practices and nomenclature, to identify normal or abnormal chromosomes.
Identify appropriate methods of specimen collection, preservation, or transport.
Input details of specimens into logs or computer systems.
Supervise subordinate laboratory staff.
Summarize test results and report to appropriate authorities.
Analyze chromosomes found in biological specimens to aid diagnoses and treatments for genetic diseases such as congenital birth defects, fertility problems, and hematological disorders.
Prepare biological specimens such as amniotic fluids, bone marrow, tumors, chorionic villi, and blood, for chromosome examinations.
Develop, implement, and monitor quality control and quality assurance programs to ensure accurate and precise test performance and reports.
Apply prepared specimen and control to appropriate grid, run instrumentation, and produce analyzable results.
Create chromosome images using computer imaging systems.
Harvest cell cultures using substances such as mitotic arrestants, cell releasing agents, and cell fixatives.
Stain slides to make chromosomes visible for microscopy.
Select banding methods to permit identification of chromosome pairs.
Evaluate appropriateness of received specimens for requested tests.
Recognize and report abnormalities in the color, size, shape, composition, or pattern of cells.
Select or prepare specimens and media for cell cultures using aseptic techniques, knowledge of medium components, or cell nutritional requirements.

Related Technology & Tools

Slide cassettes
Vortex mixers
Automatic slide loading systems
Hot air sterilizers
pH meters
Steam autoclaves
Robotic harvesters
Microscope slides
Glass flasks
Reference thermometers
Phase contrast microscopes
Laboratory freezers
Flat bottom microtiter plates
Fluorescent in situ hybridization FISH automation instruments
Inverted compound microscopes
Interferometers
Digital image printers
Safety gloves
Metaphase finding system software
35m petri dishes
Fluorescent microscopes
Laboratory microwave ovens
Mercury vapor lamps
Floor model drying chambers
Automated imaging systems
Computerized karotype equipment
Water deionizers
Stereo microscopes
Masks
Cell harvesters
Bench-top autoclaves
Media filtration systems
2 ml cryovials
10 ml pipettes
Microscope camera adapters
Glass water distillers
Uncooled charge-coupled device cameras
Incubators
Biological safety cabinets
1 ml pipettes
Microarray scanners
Counting chambers
25 ml pipettes
Biological containment hoods
Low speed refrigerated centrifuges
Pipette aids
Water baths
Hybridization ovens
Desktop computers
Liquid nitrogen containers
4 ml cryovials
Tachometers
Laboratory refrigerators
Photomicroscopes
Cell culture tubes
Microscope filters
Benchtop drying chambers
Heated magnetic stirrers
Denaturation/hybridization systems
Slide sorters
Test tube racks
Ultrasonic sterilization units
Digital cameras
Binocular compound microscopes

Genetix CytoVision
Digital karyotyping software
Image capture software
Lucia Comet Assay
Genial Genetics Shire
MetaSystems Isis Color Karyotyping
Lucia Metaphase Finder
KARIO
Lucia FISH
Lucia Karyo
Cell Bioscience Automated Image Capture
Microsoft Excel
Lucia CGH
Genial Genetics iPassport QMS
Image analysis software
Geniel Genetics iGene
Lucia MFISH